CONVINCE: Colchicine for prevention of vascular inflammation in non-cardioembolic stroke

Accumulating evidence indicates that inflammation is of key importance to the destabilisation of atherosclerotic plaques. Colchicine shows anti-inflammatory effects mediated through a reduction in macrophage/monocyte activity leading to reduction in inflammatory changes which may destabilise arterial plaques and result in thromboembolism from the plaques.

The CONVINCE study is randomising participants post non-cardioembolic stoke or high-risk TIA to receive usual care or usual care plus 500 micrograms of colchicine per day. The study aims to find if adding daily low-dose colchicine to usual care shows a reduction in recurrence of non-fatal ischaemic stroke, TIA, myocardial infarction, hospitalisation for unstable angina, cardiac arrest and vascular death after ischaemic stroke between the two arms of the study.