Dr Bojlul Bahar

Bojlul has a research background in Molecular Nutrition and Immunology and he is currently pursuing research in the following areas Novel biomarkers for metabolic health The transition from a healthy state to a metabolic syndrome state is associated with a system-level shift in the cellular processes, ultimately leading to a loss of metabolic plasticity. Such a shift, when identified precisely, could be a critical checkpoint for intervention. Bojlul’s research involved developing and comparing gene transcriptional profiles from volunteers representing various metabolic syndrome stages through the application of advanced genomics and bioinformatics tools. Identification of biomarkers of metabolic health would lead to developing new diagnostic tool and effective management of metabolic syndromes. Regulation of mammalian sirtuin expression Sirtuins regulate cascades of genes, driving crucial intracellular processes (inflammasome activation, oxidative stress, circadian clock, ageing) leading to diseases. Hence, regulation of sirtuin expression serves as one of the earliest events that lead to the activation of a diverse range of downstream signalling pathways. Bojlul’s research involves the alternation of sirtuin expression by bioactive polyphenols and assessing its effect on intracellular processes associated with metabolic health and neurodegenerative (Alzheimer’s/dementia) disease models. The integrity of the intestinal gut epithelium The integrity of the gut epithelium is vital for our immune and metabolic health. Irreversible damage to the gut epithelium caused by microbial endotoxins, food additives, pharmacological excipients causes an unregulated entry of toxic compounds and harmful microorganism into the bloodstream. Bojlul has investigated the role of bacterial lipopolysaccharides and intracellular immune signalling pathways and developing nutritional strategies for preventing chronic inflammatory diseases such as inflammatory bowel disease and type-2 diabetes.